Which of the following is a sign of opioid withdrawal?

• A. Euphoria
• B. Anhedonia
• C. Calmness
• D. Dysphoria

Answer: (D)

Dysphoria is the mood change you expect with opioid withdrawal. People going through withdrawal often feel unsettled, distressed, and unhappy rather than uplifted or content. This negative mood state contrasts with opioid intoxication, where euphoria is common, and it’s not aligned with withdrawal symptoms like agitation and autonomic symptoms.

Euphoria indicates the opposite state—being high—which points to ongoing intoxication, not withdrawal. Calmness suggests sedation or relief that comes with using rather than withdrawing. Anhedonia, while it can occur in mood disorders or in withdrawal, is not as characteristic as the clearly distressing mood of dysphoria.

So, the best sign of opioid withdrawal among these is dysphoria.