Which of the following is the generic name for the opioid overdose reversal agent?

• A. Naltrexone
• B. Buprenorphine
• C. Naloxone
• D. Methadone

Answer: (C)

Naloxone is the opioid overdose reversal agent. It works by binding to mu-opioid receptors with high affinity and displacing opioid molecules, rapidly reversing respiratory depression and sedation caused by an opioid overdose. The speed of reversal is essential in emergency care, and naloxone can be given by several routes (IV, IM, intranasal) for quick effect. The generic name is naloxone (brand names include Narcan). The other drugs listed are not used for acute overdose reversal: buprenorphine is a partial opioid agonist used for treatment of dependence; methadone is a full opioid agonist used for maintenance therapy; naltrexone is an antagonist used for relapse prevention after withdrawal and can precipitate withdrawal if given during an overdose.