Which of the following is a documented effect of topiramate in alcohol use disorder treatment?

• A. Increasing heavy drinking days
• B. Increasing number of days abstinent
• C. Causing sustained liver failure
• D. Eliminating all cravings instantly

Answer: (B)

Topiramate helps reduce drinking by dampening the reinforcing effects of alcohol, which often leads people to spend more days without alcohol. In clinical trials for alcohol use disorder, a documented outcome is an increased number of days abstinent. It can also reduce cravings, but it does not instantly or universally eliminate them. It does not produce the other effects listed—there’s no evidence that it increases heavy drinking days or causes sustained liver failure as a direct result. So the correct takeaway is that topiramate is associated with more days abstinent.