Which of the following are among the most common symptoms of methamphetamine withdrawal?

• A. Paranoia and abdominal upset
• B. Insomnia and decreased appetite
• C. Hallucinations and tremors
• D. Fatigue and depression

Answer: (D)

Fatigue with depressed mood during methamphetamine withdrawal is the most common presentation. When meth use stops, the body undergoes a crash—people often feel extreme tiredness, low energy, and a down mood as the brain readjusts after a stimulant surge in dopamine and other neurotransmitters. This combination of fatigue and depression is repeatedly described in withdrawal patterns, sometimes accompanied by sleep changes and increased appetite, but the core and most common feature is the fatigue-depression pairing. The other options describe symptoms more typical of intoxication, less common withdrawal effects, or sleep/appetite changes that don’t fit the usual withdrawal picture as closely.