What is the typical daily dose range for bupropion when used for tobacco cessation?

• A. 50-100 mg daily
• B. 300-450 mg daily
• C. 150-300 mg daily
• D. 400-600 mg daily

Answer: (C)

Dosing bupropion for tobacco cessation aims to reach a level that reduces nicotine withdrawal and cravings while keeping side effects and seizure risk manageable. The usual approach starts with a low amount to improve tolerability, then increases to a total daily dose that is effective yet safe. Practically, that means beginning with 150 mg once daily for a few days, then moving to a regimen of 150 mg twice daily for a total of 300 mg per day. This 150–300 mg per day range provides the needed therapeutic effect with the lowest acceptable risk. Doses above 300 mg daily raise the seizure risk and are not recommended for smoking cessation.