Nervousness, tremor, agitation, and hypotension may occur from abrupt discontinuation of BLANK.

• A. Benzodiazepines
• B. Barbiturates
• C. Alcohol
• D. Opioids

Answer: (B)

Abrupt cessation of a substance that enhances GABA activity can lead to withdrawal with CNS and autonomic hyperreactivity. Barbiturates increase the duration of GABA-A receptor–mediated chloride channel opening, producing strong CNS depression during use. When dependence has formed and the drug is stopped suddenly, the inhibitory effect disappears and the nervous system rebounds, causing nervousness, tremor, and agitation as the brain tries to regain balance. Autonomic instability commonly accompanies this rebound, which can include changes in blood pressure such as hypotension in some individuals. This withdrawal pattern is typically more severe and protracted with barbiturates than with other depressants, making it the best fit for these symptoms.