GABA is excitatory or inhibitory?

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Multiple Choice

GABA is excitatory or inhibitory?

Explanation:
GABA is the primary inhibitory neurotransmitter in the adult brain. When GABA binds to GABA-A receptors, it opens chloride channels, allowing Cl- to flow into the neuron. This influx hyperpolarizes the cell, making it less likely to fire an action potential. GABA-B receptors, a separate receptor type, are GPCRs that promote potassium efflux or reduce calcium entry, also yielding inhibition of neuronal activity. While in early development GABA can be excitatory because of higher intracellular chloride, in the mature CNS its action is inhibitory. This inhibitory effect underlies the calming and anticonvulsant actions of many GABA-enhancing medications.

GABA is the primary inhibitory neurotransmitter in the adult brain. When GABA binds to GABA-A receptors, it opens chloride channels, allowing Cl- to flow into the neuron. This influx hyperpolarizes the cell, making it less likely to fire an action potential. GABA-B receptors, a separate receptor type, are GPCRs that promote potassium efflux or reduce calcium entry, also yielding inhibition of neuronal activity. While in early development GABA can be excitatory because of higher intracellular chloride, in the mature CNS its action is inhibitory. This inhibitory effect underlies the calming and anticonvulsant actions of many GABA-enhancing medications.

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