Bupropion (Wellbutrin) mimics the effects of nicotine by increasing which neurotransmitters?

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Prepare for the Certified Addictions Registered Nurse (CARN) Advanced Practice Test. Utilize flashcards and multiple-choice questions, complete with hints and explanations. Boost your readiness for the exam!

Multiple Choice

Bupropion (Wellbutrin) mimics the effects of nicotine by increasing which neurotransmitters?

Explanation:
Bupropion increases dopamine and norepinephrine by blocking their reuptake, boosting these neurotransmitters in brain circuits involved in reward and mood. This rise helps blunt nicotine withdrawal and cravings, since nicotine’s addictive effect largely hinges on dopaminergic signaling. Serotonin and GABA aren’t the primary targets of bupropion, and acetylcholine or glutamate are not the main pathways it modulates for its smoking-cessation and antidepressant effects. So the best-fitting pairing is dopamine and norepinephrine.

Bupropion increases dopamine and norepinephrine by blocking their reuptake, boosting these neurotransmitters in brain circuits involved in reward and mood. This rise helps blunt nicotine withdrawal and cravings, since nicotine’s addictive effect largely hinges on dopaminergic signaling. Serotonin and GABA aren’t the primary targets of bupropion, and acetylcholine or glutamate are not the main pathways it modulates for its smoking-cessation and antidepressant effects. So the best-fitting pairing is dopamine and norepinephrine.

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