Acamprosate (Campral) dosing is which of the following?

• A. 333 mg PO daily
• B. 600 mg PO daily
• C. 100 mg PO daily
• D. 2 g PO daily

Answer: (A)

Acamprosate needs to be taken in divided doses to maintain steady drug levels and support ongoing abstinence from alcohol. The standard maintenance regimen is 666 mg per dose, taken three times daily, which totals about 2,000 mg (roughly 2 g) per day. This dosing is typically given as two 333 mg tablets with each of the three daily doses, often taken with meals. Dosing options that provide only a small daily total—such as 333 mg once daily, 600 mg daily, or 100 mg daily—do not achieve the necessary exposure for efficacy. The approximate 2 g per day regimen is the most consistent with how acamprosate is intended to be used.